Antioxidants, Free Full-Text

Exposure to high doses of radiation, accidental or therapeutic, often results in gastrointestinal (GI) injury. To date, there are no therapies available to mitigate GI injury after radiation exposure. Gamma-tocotrienol (GT3) is a promising radioprotector under investigation in nonhuman primates (NHP). We have shown that GT3 has radioprotective function in intestinal epithelial and crypt cells in NHPs exposed to 12 Gy total-body irradiation (TBI). Here, we determined GT3 potential in accelerating the GI recovery in partial-body irradiated (PBI) NHPs using X-rays, sparing 5% bone marrow. Sixteen rhesus macaques were treated with either vehicle or GT3 24 h prior to 12 Gy PBI. Structural injuries and crypt survival were examined in proximal jejunum on days 4 and 7. Plasma citrulline was assessed using liquid chromatography–tandem mass spectrometry (LC-MS/MS). Crypt cell proliferation and apoptotic cell death were evaluated using Ki-67 and TUNEL staining. PBI significantly decreased mucosal surface area and reduced villous height. Interestingly, GT3 increased crypt survival and enhanced stem cell proliferation at day 4; however, the effects seemed to be minimized by day 7. GT3 did not ameliorate a radiation-induced decrease in citrulline levels. These data suggest that X-rays induce severe intestinal injury post-PBI and that GT3 has minimal radioprotective effect in this novel model.

Antioxidants, Free Full-Text

Illustrations of antioxidants fighting against free radicals by

Free radical scavengers: An overview on heterocyclic advances and medicinal prospects - ScienceDirect

Antioxidants, Free Full-Text, draw it to know it

Frontiers Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

IJMS, Free Full-Text

Antioxidants, Free Full-Text, giro gratis coin master levvvel

Antioxidants, Free Full-Text, renato ruiz pacheco

(4 PACK) - Vitabiotics Immunace Tablets 30s 4 PACK Fantastic quality product from a great Vitabiotics Ltd

Antioxidants protect cells from damage caused by free radicals. They scavenge free radicals from the body cells and reduce the damage caused by

Antioxidants for the Prevention and Treatment of Non-communicable Diseases

PDF) Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev 4:118-126